Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial.
We aimed to understand how Lacticaseibacillus rhamnosus IDCC 3201 (RH 3201) affects irritable bowel syndrome with constipation (IBS-C) through a thorough study. In a randomized, double-blind trial, 30 participants took either RH 3201 or a placebo for 8 weeks.
Those taking RH 3201 experienced significant improvements, including fewer bowel discomforts and reduced bloating issues. We also observed an increase in certain beneficial gut bacteria and a link between specific metabolites and symptom relief. Overall, RH 3201 shows promise as an effective treatment for IBS-C.
Read More
8
Lactobacillus rhamnosus protects gut barrier
Lactobacillus rhamnosus GG prevents epithelial barrier dysfunction induced by interferon-gamma and fecal supernatants from irritable bowel syndrome patients in human intestinal enteroids and colonoids.
We explored how Lactobacillus rhamnosus GG (LGG) interacts with intestinal barrier functions in the context of irritable bowel syndrome (IBS). Using human intestinal models, we found that LGG helps maintain barrier integrity when challenged with harmful substances from IBS patients.
Our findings revealed that LGG can prevent damage to tight junction proteins and lower permeability of the gut lining. However, LGG's beneficial effects were not replicated with its cell wall extracts, DNA, or boiled forms, indicating the importance of its live metabolites. This suggests that LGG may be a promising way to support gut health in IBS.
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8
Inulin aids IBS-C symptom management
Effect of inulin in the treatment of irritable bowel syndrome with constipation (Review).
We explored the impact of inulin on irritable bowel syndrome (IBS), particularly focusing on its effect for those suffering from constipation. IBS is a widespread issue that brings significant social and financial burdens.
Our investigation revealed that inulin appears to play a beneficial role in managing symptoms by influencing bowel movements and improving stool consistency. It does this by altering the gut microbiota, which is increasingly recognized as an important factor in gastrointestinal health.
However, while the positive outcomes of inulin for IBS patients with constipation seem promising, more large-scale, randomized clinical trials are necessary to strengthen this evidence. It’s essential to ensure the findings are backed by solid data so that patients can confidently consider inulin as a viable treatment option.
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Most Useful Reviews
7.5
Improved bowel function
Great probiotics! I noticed an improvement in my bowel function after using antibiotics. I'm satisfied!
Read More
7.5
Effective digestion aid
This product is effective in addressing gas, bowel movements, and digestion, although it is rather pricey. It also helps with my gastritis, which is a relief when dealing with irritable bowel syndrome.
Read More
7.5
Comfortable bowel movements
I purchased the LG Lactobacillus for a significant 20 billion won, which made my bowel movements comfortable and alleviated any discomfort in my intestines.
Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial.
We aimed to understand how Lacticaseibacillus rhamnosus IDCC 3201 (RH 3201) affects irritable bowel syndrome with constipation (IBS-C) through a thorough study. In a randomized, double-blind trial, 30 participants took either RH 3201 or a placebo for 8 weeks.
Those taking RH 3201 experienced significant improvements, including fewer bowel discomforts and reduced bloating issues. We also observed an increase in certain beneficial gut bacteria and a link between specific metabolites and symptom relief. Overall, RH 3201 shows promise as an effective treatment for IBS-C.
Read More
9
Lactobacillus rhamnosus improves IBS symptoms
[Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with irritable bowel syndrome with diarrhea and antibiotic-associated diarrhea].
We explored how Lactobacillus rhamnosus, part of a complex probiotic called Neobiotic Lactobalance®, impacts patients with irritable bowel syndrome (IBS) with diarrhea and antibiotic-associated diarrhea (AAD).
In a 21-day study involving 54 patients, significant improvements were noted. Diarrheal symptoms in IBS patients dropped markedly from 17 to 6 points, while AAD symptoms fell from 13 to just 3 points.
Overall, we saw that this probiotic not only normalized gut bacteria but also substantially eased symptoms, suggesting it can be a valuable part of managing these digestive disorders.
Read More
9
Probiotics show promise for IBS
Effects of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 in IBS patients.
We investigated the effects of a new formulation containing Lactobacillus rhamnosus and Bifidobacterium longum, supplemented with vitamin B6, on patients with irritable bowel syndrome (IBS). In a well-structured, double-blind, controlled trial with 25 participants, we found significant improvements in symptoms like abdominal pain and bloating compared to placebo.
Specifically, abdominal pain decreased by nearly 49% and bloating by over 36%. Additionally, we observed enhancements in intestinal permeability and an increase in beneficial gut bacteria.
Overall, this promising treatment highlights the potential of using probiotics to manage IBS symptoms effectively.
Read More
9
Kombucha with inulin shows promise
[Efficacy of newly developed kombucha-based specialized food product for treatment of constipation-predominant irritable bowel syndrome].
We assessed the effectiveness of a non-alcoholic, fermented kombucha drink enriched with inulin and vitamins on individuals with constipation-predominant irritable bowel syndrome (IBS). This innovative study involved 40 participants who were randomly assigned to receive either the kombucha drink or plain water over a span of 10 days.
Our findings highlighted that those who consumed the kombucha drink experienced a notable increase in stool frequency—moving from an average of 0.60 to 0.85 bowel movements per day. Furthermore, the consistency of their stools improved significantly, indicating a shift from harder to softer stools, which benefits IBS sufferers.
Participants also reported feeling less discomfort related to incomplete bowel emptying after drinking the kombucha. In contrast, those in the control group did not experience such improvements, underscoring the potential benefits of inulin when combined with the unique properties of kombucha.
While the study revealed valuable insights into how a kombucha-based drink can enhance bowel health, it's essential to note that some symptoms did not show significant differences between groups—implying that while inulin may help, it is not a universal remedy for all IBS-related issues. Overall, our research suggests that kombucha enriched with inulin could be a promising supplement for those struggling with IBS symptoms, particularly constipation.
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9
Inulin improves IBS symptoms
[Using a multicomponent functional food in IBS patients with constipation a comparative controlled study].
We explored the impact of a functional drink containing inulin, menthol, and pyridoxine on patients suffering from constipation-predominant irritable bowel syndrome (IBS-C). In our study, 49 participants, aged between 18 and 68 years and meeting the Rome III criteria, were divided into two groups. One group followed their standard diet plus two drinks a day for two weeks, while the control group maintained their usual diet without the drinks.
The results were promising. Those who consumed the functional drink experienced a notable improvement in bowel frequency and stool consistency, with an increase in daily bowel movements and a better Bristol stool scale score. Additionally, there was a significant reduction in abdominal pain, bloating, and the feeling of incomplete bowel emptying. Quality of life also received a boost, reflecting an enhanced well-being among participants.
However, we found that a significant number of participants reported experiencing heartburn after starting the treatment. This highlights the need for further adjustments in the drink’s formulation to mitigate these adverse effects. Overall, our findings suggest that a functional drink with inulin can improve various symptoms of IBS-C, while also making it clear that modifications may be necessary to address side effects like heartburn.
Great probiotics! I noticed an improvement in my bowel function after using antibiotics. I'm satisfied!
Read More
7.5
Effective digestion aid
This product is effective in addressing gas, bowel movements, and digestion, although it is rather pricey. It also helps with my gastritis, which is a relief when dealing with irritable bowel syndrome.
Read More
7.5
Comfortable bowel movements
I purchased the LG Lactobacillus for a significant 20 billion won, which made my bowel movements comfortable and alleviated any discomfort in my intestines.
Read More
Frequently Asked Questions
Irritable Bowel Syndrome (IBS) is a common gastrointestinal disorder characterized by a range of symptoms including abdominal pain, bloating, gas, and altered bowel habits, which can manifest as diarrhea, constipation, or a combination of both. The exact cause of IBS isn't fully understood, but it's believed to stem from a complex interplay of factors including gut sensitivity, changes in gut motility, and psychosocial elements such as stress or anxiety. IBS is often classified into different types based on the predominant symptoms, such as IBS with diarrhea (IBS-D), IBS with constipation (IBS-C), and a mixed type (IBS-M).
Managing IBS can be multifaceted, often requiring a tailored approach based on individual symptoms and triggers. Dietary changes are frequently recommended, including low-FODMAP diets, which involve reducing fermentable carbohydrates that can exacerbate symptoms. In addition to dietary adjustments, stress management techniques and medications aimed at addressing specific symptoms, such as anti-diarrheal agents or laxatives, may also be beneficial. Since IBS can significantly impact quality of life, consulting with a healthcare provider or a registered dietitian is essential for developing an effective management plan.
Probiotics are live microorganisms, primarily bacteria, that are intended to provide health benefits when consumed in adequate amounts. These beneficial bacteria are often referred to as "good" or "friendly" bacteria because they help maintain a balanced gut microbiome, which plays a vital role in digestion, immune function, and overall health. Probiotics can be found in various foods such as yogurt, kefir, sauerkraut, and kombucha, as well as in dietary supplements. The most common strains include Lactobacillus and Bifidobacterium, which have been studied for their positive effects on gastrointestinal health, including the alleviation of symptoms related to irritable bowel syndrome (IBS) and diarrhea.
Incorporating probiotics into your diet may help support a healthy gut by competing with harmful bacteria and promoting a more diverse microbiome. However, it's important to note that the specific effects of probiotics can vary widely depending on the strain, dosage, and individual health conditions. While many people may benefit from including probiotics in their diet, it's advisable to consult a healthcare professional before starting any new supplement regimen, especially if you have underlying health issues or concerns. For those looking to explore the world of probiotics, it’s worth experimenting with various sources to find what works best for your body.
Probiotics may offer some benefits for individuals suffering from Irritable Bowel Syndrome (IBS), although results can vary from person to person. Research indicates that certain strains of probiotics can help alleviate symptoms such as bloating, gas, and changes in bowel habits. The mechanism is thought to involve the modulation of gut bacteria, which helps improve gut health and might lead to better digestion and reduced inflammation. For those with IBS, specific strains like Bifidobacterium and Lactobacillus have been examined in studies and have shown promise in reducing abdominal pain and discomfort.
However, it’s important to approach probiotic use with caution, as not all probiotics are created equal. The effectiveness often depends on the specific strain and the dosage. A well-formulated probiotic supplement, combined with a diet tailored to IBS needs, could provide additional support. It's advisable for individuals considering probiotics for IBS to consult with a healthcare provider to ensure that they choose the appropriate strains and dosages tailored for their unique symptoms. Overall, while probiotics may not be a cure-all for IBS, they can be a helpful tool in managing symptoms for some individuals.
Based on user reviews, the timeline for experiencing results from this supplement when addressing Irritable Bowel Syndrome (IBS) can vary. Some users have reported noticing improvements in bowel function relatively quickly after starting the supplement, particularly in relation to issues such as gas and bowel movements. For instance, one user mentioned an enhancement in bowel function after using antibiotics, indicating they felt satisfied with their progress soon after starting the supplement Read Review.
Another reviewer highlighted that the product effectively addressed gas and digestion, implying beneficial effects on IBS symptoms were felt promptly, despite some concerns about the price Read Review. Overall, it seems users generally expect to see noticeable effects shortly after beginning the use of the supplement, though individual experiences may vary.
The research surrounding the use of probiotics, particularly Lactobacillus rhamnosus, shows promising potential for treating Irritable Bowel Syndrome (IBS). For instance, a study indicated that a specific probiotic blend including Lactobacillus rhamnosus significantly improved intestinal barrier integrity and reduced permeability in IBS patients, suggesting a beneficial role in gut health [1]. Another randomized trial found that participants receiving a combination of sodium butyrate, probiotics, and fructooligosaccharides reported significant symptom relief, improving their quality of life within four weeks [2]. Notably, research has highlighted that Lactobacillus rhamnosus specifically helps alleviate symptoms in IBS patients with diarrhea and constipation [5][3].
However, while these findings are encouraging, the broader consensus points to a need for further investigation. Several studies emphasize that results can vary significantly among individuals, and some treatments have shown limited effectiveness or inconclusive results [15][16]. Therefore, while there is scientific backing for certain probiotic strains in managing IBS symptoms, further robust research is essential to establish definitive conclusions about their overall effectiveness in treating this complex condition.
Users have reported various improvements in their symptoms after using this supplement, particularly in relation to bowel function and digestion. For example, one user found relief from discomfort and a noticeable enhancement in bowel movements after using the product following a course of antibiotics Read Review. Another reviewer mentioned that it effectively addressed issues such as gas and digestion, providing relief not only from IBS symptoms but also from gastritis Read Review.
Additionally, a user highlighted improved comfort during bowel movements and a reduction of intestinal discomfort after their purchase, emphasizing the product's effectiveness Read Review. While many users appear satisfied and report beneficial effects, it's essential to remember that individual experiences can vary widely depending on personal health conditions and responses to the supplement.
Users report a generally positive experience when combining this supplement with other probiotics or digestive aids. For instance, one reviewer noted that they experienced an improvement in bowel function after utilizing antibiotics along with this probiotic, suggesting that the combination helped restore their gut health effectively Read Review.
Additionally, another user indicated that the supplement was effective in addressing issues such as gas and digestion, which can be common concerns for those dealing with Irritable Bowel Syndrome (IBS). They mentioned relief from both IBS symptoms and gastritis, highlighting the product's multifaceted benefits when paired with their existing supplements Read Review. Overall, while individual responses may vary, many users believe that combining this supplement with other digestive aids can enhance overall gut health and relieve IBS symptoms.
Users report positive outcomes regarding the use of probiotics for treating Irritable Bowel Syndrome (IBS), emphasizing the importance of finding the right dosage. For instance, one user mentioned that after using probiotics post-antibiotics, they noticed a significant improvement in bowel function, suggesting that the right dosage can enhance overall gastrointestinal health Read Review. Another user highlighted that probiotics effectively addressed issues such as gas and digestion, which are common concerns for those with IBS Read Review.
Moreover, specific strains and dosages seem to play a critical role as one user noted that a product containing LG Lactobacillus with a high potency of 20 billion helped ease their bowel discomfort Read Review. This indicates that users find higher doses beneficial, but the exact right amount may vary based on individual responses and specific IBS symptoms. A nuanced approach, possibly guided by a healthcare professional, may be essential for achieving the best results.
7.5
Improved bowel function
Great probiotics! I noticed an improvement in my bowel function after using antibiotics. I'm satisfied!
7.5
Effective digestion aid
This product is effective in addressing gas, bowel movements, and digestion, although it is rather pricey. It also helps with my gastritis, which is a relief when dealing with irritable bowel syndrome.
7.5
Comfortable bowel movements
I purchased the LG Lactobacillus for a significant 20 billion won, which made my bowel movements comfortable and alleviated any discomfort in my intestines.
8
Probiotics may benefit IBS treatment
A Probiotic Mixture of LR 32, BL 04, and BB 536 Counteracts the Increase in Permeability Induced by the Mucosal Mediators of Irritable Bowel Syndrome by Acting on Zonula Occludens 1.
We explored how a special probiotic mix, including Lactobacillus rhamnosus, affects patients with Irritable Bowel Syndrome (IBS). Using an in vitro model, we found that this blend significantly improved the integrity of the intestinal barrier when exposed to substances from IBS patients.
Specifically, it helped to reduce the permeability issues caused by these substances, especially in patients with diarrhea and mixed bowel habits. Overall, this research suggests that probiotics like Lactobacillus rhamnosus can potentially support gut health in IBS.
7
Probiotics may alleviate IBS symptoms
Efficacy and Safety of a Mixture of Microencapsulated Sodium Butyrate, Probiotics, and Short Chain Fructooligosaccharides in Patients with Irritable Bowel Syndrome-A Randomized, Double-Blind, Placebo-Controlled Study.
We investigated the effectiveness and safety of a combination of microencapsulated sodium butyrate, probiotics, and short-chain fructooligosaccharides in people with irritable bowel syndrome (IBS).
In a randomized, double-blind, placebo-controlled trial with 120 adults, participants receiving the biotic mixture showed significant symptom relief by four weeks, with improved quality of life noted.
While some measures indicated benefits, like less urgency to defecate, other evaluations revealed no major differences between the treatment and placebo groups. Overall, this approach was found to be safe and well tolerated.
9
Lactobacillus rhamnosus improves IBS symptoms
[Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with irritable bowel syndrome with diarrhea and antibiotic-associated diarrhea].
We explored how Lactobacillus rhamnosus, part of a complex probiotic called Neobiotic Lactobalance®, impacts patients with irritable bowel syndrome (IBS) with diarrhea and antibiotic-associated diarrhea (AAD).
In a 21-day study involving 54 patients, significant improvements were noted. Diarrheal symptoms in IBS patients dropped markedly from 17 to 6 points, while AAD symptoms fell from 13 to just 3 points.
Overall, we saw that this probiotic not only normalized gut bacteria but also substantially eased symptoms, suggesting it can be a valuable part of managing these digestive disorders.
9
Effective treatment for IBS-C
Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial.
We aimed to understand how Lacticaseibacillus rhamnosus IDCC 3201 (RH 3201) affects irritable bowel syndrome with constipation (IBS-C) through a thorough study. In a randomized, double-blind trial, 30 participants took either RH 3201 or a placebo for 8 weeks.
Those taking RH 3201 experienced significant improvements, including fewer bowel discomforts and reduced bloating issues. We also observed an increase in certain beneficial gut bacteria and a link between specific metabolites and symptom relief. Overall, RH 3201 shows promise as an effective treatment for IBS-C.
5
Probiotic mixture offers limited IBS relief
Effect of administering a multi-species probiotic mixture on the changes in fecal microbiota and symptoms of irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial.
We explored how a multi-species probiotic mixture, including Lactobacillus rhamnosus, affects patients with irritable bowel syndrome (IBS). In a study with 81 participants, we observed that after four weeks, those who took the probiotic had higher levels of beneficial bacteria and reported better relief from certain symptoms, particularly diarrhea. However, overall symptom improvement was similar between those receiving the probiotics and the placebo group. While our results show promise, they highlight that probiotics alone may not fully resolve IBS symptoms for everyone.
4
Probiotics show promise for children
The use of probiotics in pediatric gastroenterology: a review of the literature and recommendations by Latin-American experts.
We reviewed existing literature on probiotics for children’s gastrointestinal issues, including their potential benefits and safety. The expert consensus highlights that Lactobacillus rhamnosus GG is recommended for managing various conditions, such as intestinal infections and colic, earning a solid recommendation score.
However, we found that while Lactobacillus rhamnosus may help improve symptoms of irritable bowel syndrome, the evidence is limited. Therefore, its effectiveness in this area remains uncertain and requires further investigation.
References
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Gąsiorowska A, Romanowski M, Walecka-Kapica E, Kaczka A, Chojnacki C, et al. Efficacy and Safety of a Mixture of Microencapsulated Sodium Butyrate, Probiotics, and Short Chain Fructooligosaccharides in Patients with Irritable Bowel Syndrome-A Randomized, Double-Blind, Placebo-Controlled Study. J Clin Med. 2024;14. 10.3390/jcm14010006
Kwon H, Nam EH, Kim H, Jo H, Bang WY, et al. Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial. Sci Rep. 2024;14:22384. 10.1038/s41598-024-72887-x
Zhang L, Ni X, Jiang M, Du M, Zhang S, et al. Strains for Alleviation of Irritable Bowel Disease and Chronic Fatigue Syndrome. Microorganisms. 2024;12. 10.3390/microorganisms12061081
Drozdov VN, Shikh EV, Astapovskii AA, Khalaidzheva KN, Solovieva SA, et al. [Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with irritable bowel syndrome with diarrhea and antibiotic-associated diarrhea]. Vopr Pitan. 2023;92:92. 10.33029/0042-8833-2023-92-4-92-103
Skrzydło-Radomańska B, Prozorow-Król B, Cichoż-Lach H, Majsiak E, Bierła JB, et al. The Effectiveness of Synbiotic Preparation Containing and Probiotic Strains and Short Chain Fructooligosaccharides in Patients with Diarrhea Predominant Irritable Bowel Syndrome-A Randomized Double-Blind, Placebo-Controlled Study. Nutrients. 2020;12. 10.3390/nu12071999
Bonfrate L, Di Palo DM, Celano G, Albert A, Vitellio P, et al. Effects of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 in IBS patients. Eur J Clin Invest. 2020;50:e13201. 10.1111/eci.13201
Ding FCL, Karkhaneh M, Zorzela L, Jou H, Vohra S. Probiotics for paediatric functional abdominal pain disorders: A rapid review. Paediatr Child Health. 2019;24:383. 10.1093/pch/pxz036
Nocerino R, Di Costanzo M, Bedogni G, Cosenza L, Maddalena Y, et al. Dietary Treatment with Extensively Hydrolyzed Casein Formula Containing the Probiotic Lactobacillus rhamnosus GG Prevents the Occurrence of Functional Gastrointestinal Disorders in Children with Cow's Milk Allergy. J Pediatr. 2019;213:137. 10.1016/j.jpeds.2019.06.004
Hojsak I. Probiotics in Functional Gastrointestinal Disorders. Adv Exp Med Biol. 2019;1125:121. 10.1007/5584_2018_321
Han X, Lee A, Huang S, Gao J, Spence JR, et al. Lactobacillus rhamnosus GG prevents epithelial barrier dysfunction induced by interferon-gamma and fecal supernatants from irritable bowel syndrome patients in human intestinal enteroids and colonoids. Gut Microbes. 2019;10:59. 10.1080/19490976.2018.1479625
Preston K, Krumian R, Hattner J, de Montigny D, Stewart M, et al. Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R and Lactobacillus rhamnosus CLR2 improve quality-of-life and IBS symptoms: a double-blind, randomised, placebo-controlled study. Benef Microbes. 2018;9:697. 10.3920/BM2017.0105
Wegh CAM, Benninga MA, Tabbers MM. Effectiveness of Probiotics in Children With Functional Abdominal Pain Disorders and Functional Constipation: A Systematic Review. J Clin Gastroenterol. 2018;52 Suppl 1, Proceedings from the 9th Probiotics, Prebiotics and New Foods, Nutraceuticals and Botanicals for Nutrition & Human and Microbiota Health Meeting, held in Rome, Italy from September 10 to 12, 2017:S10. 10.1097/MCG.0000000000001054
Darbaky Y, Evrard B, Patrier S, Falenta J, Garcin S, et al. Oral probiotic treatment of Lactobacillus rhamnosus Lcr35 prevents visceral hypersensitivity to a colonic inflammation and an acute psychological stress. J Appl Microbiol. 2017;122:188. 10.1111/jam.13320
Yoon H, Park YS, Lee DH, Seo JG, Shin CM, et al. Effect of administering a multi-species probiotic mixture on the changes in fecal microbiota and symptoms of irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial. J Clin Biochem Nutr. 2015;57:129. 10.3164/jcbn.15-14
Cruchet S, Furnes R, Maruy A, Hebel E, Palacios J, et al. The use of probiotics in pediatric gastroenterology: a review of the literature and recommendations by Latin-American experts. Paediatr Drugs. 2015;17:199. 10.1007/s40272-015-0124-6
Koc F, Arendt E, Coffey A, Ross RP, Stanton C. Impact of low FODMAP sourdough bread on gut microbiota using an colonic fermentation model. Front Microbiol. 2024;15:1496022. 10.3389/fmicb.2024.1496022
Andreozzi V, Cuoco S, Balestrieri M, Fierro F, Ferrara N, et al. Synbiotic supplementation may globally improve non-motor symptoms in patients with stable Parkinson's disease: results from an open label single-arm study. Sci Rep. 2024;14:23095. 10.1038/s41598-024-74400-w
Garvey SM, LeMoire A, Wang J, Lin L, Sharif B, et al. Safety and Tolerability of Microbial Inulinase Supplementation in Healthy Adults: A Randomized, Placebo-Controlled Trial. Gastro Hep Adv. 2024;3:920. 10.1016/j.gastha.2024.05.013
Isakov VA, Pilipenko VI, Vlasova AV, Kochetkova AA. Evaluation of the Efficacy of Kombucha-Based Drink Enriched with Inulin and Vitamins for the Management of Constipation-Predominant Irritable Bowel Syndrome in Females: A Randomized Pilot Study. Curr Dev Nutr. 2023;7:102037. 10.1016/j.cdnut.2023.102037
Pilipenko VI, Isakov VA, Morozov SV, Vlasova AV, Kochetkova AA. [Efficacy of newly developed kombucha-based specialized food product for treatment of constipation-predominant irritable bowel syndrome]. Vopr Pitan. 2022;91:95. 10.33029/0042-8833-2022-91-5-95-104
Ochoa KC, Samant S, Liu A, Duysburgh C, Marzorati M, et al. In Vitro Efficacy of Targeted Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols Enzymatic Digestion in a High-Fidelity Simulated Gastrointestinal Environment. Gastro Hep Adv. 2023;2:283. 10.1016/j.gastha.2022.10.011
Bărboi OB, Chirilă I, Ciortescu I, Anton C, Drug VL. Inulin, Choline and Silymarin in the Treatment of Irritable Bowel Syndrome with Constipation-Randomized Case-Control Study. J Clin Med. 2022;11. 10.3390/jcm11082248
Gunn D, Abbas Z, Harris HC, Major G, Hoad C, et al. Psyllium reduces inulin-induced colonic gas production in IBS: MRI and fermentation studies. Gut. 2022;71:919. 10.1136/gutjnl-2021-324784
Bărboi OB, Ciortescu I, Chirilă I, Anton C, Drug V. Effect of inulin in the treatment of irritable bowel syndrome with constipation (Review). Exp Ther Med. 2020;20:185. 10.3892/etm.2020.9315
Ahluwalia B, Magnusson MK, Böhn L, Störsrud S, Larsson F, et al. Randomized clinical trial: Effects of Aloe barbadensis Mill. extract on symptoms, fecal microbiota and fecal metabolite profiles in patients with irritable bowel syndrome. Neurogastroenterol Motil. 2020;32:e13860. 10.1111/nmo.13860
Abhari K, Saadati S, Hosseini-Oskouiee F, Yari Z, Hosseini H, et al. Is Bacillus coagulans supplementation plus low FODMAP diet superior to low FODMAP diet in irritable bowel syndrome management?. Eur J Nutr. 2020;59:2111. 10.1007/s00394-019-02060-y
Baştürk A, Artan R, Yılmaz A. Efficacy of synbiotic, probiotic, and prebiotic treatments for irritable bowel syndrome in children: A randomized controlled trial. Turk J Gastroenterol. 2016;27:439. 10.5152/tjg.2016.16301
Major G, Pritchard S, Murray K, Alappadan JP, Hoad CL, et al. Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome. Gastroenterology. 2017;152:124. 10.1053/j.gastro.2016.09.062
Pilipenko VI, Teplyuk DA, Shakhovskaya AK, Isakov VA, Vorobyova VM, et al. [Using a multicomponent functional food in IBS patients with constipation a comparative controlled study]. Vopr Pitan. 2016;85:84.
Bogovič Matijašić B, Obermajer T, Lipoglavšek L, Sernel T, Locatelli I, et al. Effects of synbiotic fermented milk containing Lactobacillus acidophilus La-5 and Bifidobacterium animalis ssp. lactis BB-12 on the fecal microbiota of adults with irritable bowel syndrome: A randomized double-blind, placebo-controlled trial. J Dairy Sci. 2016;99:5008. 10.3168/jds.2015-10743
Pilipenko VI, Teplyuk DA, Shakhovskaya AK, Isakov VA, Vorobyova VM, et al. [Dry jelly concentrate with vitamins and dietary fiber in patients with IBS with constipation: a comparative controlled study]. Vopr Pitan. 2015;84:83.